|dc.description.abstract||The study was done to evaluate antibacterial activity in Senna didymobotrya roots
methanolic-aqua extract and the selected fractions against selected pathogenic
bacterial organisms. The aqueous fraction of S. didymobotrya root inhibited
B.cereus giving the best results followed by Salmonella typhi, P.vulgaris, S.
liquefaciens and E. coli respectively. There was no inhibition for E. aerogenes.
Analysis of variance (ANOVA) showed that the organisms were significantly
different in the zones of inhibition (p< 0.05). The ethyl acetate fraction of S.
didymobotrya root extract inhibited B. cereus the best followed by, Salmonella
typhi, P.vulgaris, S. liquefaciens and E. coli respectively(Table 1). The extract
fraction did not inhibit E. aerogenes. The crude extract of S. didymobotrya root
inhibited all the organisms, with the best zone of inhibition been that of Bacillus
cereus (29.67±0.882), followed by P.vulgaris (16.67±0.667), Salmonella typhi
(15.67±0.667), E. coli (13.33± 0.667), E. aerogenes (12.00±0.000) and Serratia
liquefaciens (11.33±0.667). These results have shown that S. didymobotrya extract
show significant activity against all the organisms tested. The inhibition of the
plant roots extract to the growth of all the organisms greatly depicts the plant roots
to have great potency towards the treatment of diseases caused by the organisms.
The antibacterial activity of the plant roots is due to the presence of important
phytochemicals as observed in previous studies. Further research needs to be done
in order to isolate the active compounds, their structural elucidation, mode of action
and their effect in the in vivo environment.||en_US