The diagnosis of cancer is a tough affair resulting to significant emotional anguish. Patients with both anxiety and depressive disorders tend to have drastic symptoms, extended healing periods, worse outcomes, and greater burden on healthcare resources than those with a singular disorder. The objective of this research was to determine the prevalence of anxiety and depression and to explore factors associated with these psychiatric disorders among cancer patients. A cross- sectional data was obtained from 195 patients drawn from cancer patients that were receiving cancer treatment on outpatient basis at Texas cancer centre, Nairobi Kenya. Socio-demographic, socioeconomic and clinical information were obtained from these patients using a self-administered questionnaire. An English version of Hospital anxiety and depression scale was used to assess for anxiety and depression in this population. Chi square was used to test the differences in categorical indicators while Logistic regression was performed to investigate the association between sociodemographic, socioeconomic and clinical factors with both anxiety and depression. A prevalence of 33.3% and 39.0% for anxiety and depression was obtained. After adjustment, those who had prostate cancer were 6.73 times more likely to be anxious than those who had cancers of the breast or female genital organ. Participants who were in the late stages, were paying for their treatment in cash and had severe pain were 8.54, 4.46 and 29.47 times more likely to be anxious. However, those who had family history of cancer and had counselling support were 88% and 78% less likely to be anxious than those who did not have family history of cancer and did not have counselling support, respectively, after adjusting for potential confounders. Patients who had cancers of the soft tissues or bones and cancers of the central nervous system or hepatobiliary or lungs were more likely to be depressed. However, those who had counselling support and were engaged in a support group were 56% and 92% less likely to be depressed. The prevalence of anxiety and depression among cancer patients was high indicating need for routine screening of this psychological condition in oncological care. Mitigation measures of this conditions such as counselling, support groups aimed assisting patients cope with cancer and its impact on their mental wellbeing is vital.